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Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia.Avoid use of DUEXIS in patients with severe heart failure unless benefits are expected to outweigh the risk.Monitor blood pressure closely with DUEXIS treatment. Hypertension can occur with NSAID treatment.DUEXIS should be discontinued immediately if clinical signs and symptoms consistent with liver disease develop. Elevation of one or more liver tests may occur during therapy with NSAIDs.Discontinue DUEXIS if active and clinically significant bleeding from any source occurs.If DUEXIS is used in patients with a recent MI, monitor patients for signs of cardiac ischemia. Avoid use of DUEXIS in patients with a recent MI unless benefits are expected to outweigh the risk of recurrent CV thrombotic events.The concurrent use of aspirin and an NSAID, such as DUEXIS, increases the risk of serious GI events. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.Use ibuprofen at the lowest effective dose for the shortest duration consistent with individual patient treatment goals.In the setting of coronary artery bypass graft (CABG) surgery.Fatal anaphylactic reactions to NSAIDs have been reported in such patients Who have a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.With a known hypersensitivity to ibuprofen or famotidine or any components of the drug product or known hypersensitivity to other H 2-receptor antagonists.

DUEXIS ® (IBUPROFEN AND FAMOTIDINE) IMPORTANT SAFETY INFORMATION CONTRAINDICATIONS

Enfamil samples for healthcare providers